Publications

Journal articles

  1. van Valkenhoef, G., Tervonen, T., & Postmus, D. (2014). Notes on ’Hit-And-Run enables efficient weight generation for simulation-based multiple criteria decision analysis.’ European Journal of Operational Research. in press. [preprint] [doi]
  2. Postmus, D., Tervonen, T., van Valkenhoef, G., Hillege, H., & Buskens, E. (2013). A multi-criteria decision analysis perspective on the health economic evaluation of medical interventions. The European Journal of Health Economics. in press. [preprint] [doi]
  3. van Valkenhoef, G., & Ades, A. E. (2013). Evidence synthesis assumes additivity on the scale of measurement: response to ’rank reversal in indirect comparisons’ by Norton et al. Value in Health, 16, 449–451. [preprint] [doi]
  4. Tervonen, T., van Valkenhoef, G., Basturk, N., & Postmus, D. (2012). Hit-And-Run enables efficient weight generation for simulation-based multiple criteria decision analysis. European Journal of Operational Research, 224(3), 552–559. [preprint] [webpage] [doi]
  5. van Valkenhoef, G., Tervonen, T., de Brock, B., & Hillege, H. (2012). Deficiencies in the transfer and availability of clinical trials evidence: a review of existing systems and standards. BMC Medical Informatics and Decision Making, 12, 95. [preprint] [doi]
  6. van Valkenhoef, G., Lu, G., de Brock, B., Hillege, H., Ades, A. E., & Welton, N. J. (2012). Automating network meta-analysis. Research Synthesis Methods, 3(4), 285–299. [preprint] [doi]
  7. Tervonen, T. (2012). JSMAA: open source software for SMAA computations. International Journal of Systems Science, in press. [doi]
  8. van Valkenhoef, G., Tervonen, T., Zwinkels, T., de Brock, B., & Hillege, H. (2013). ADDIS: a decision support system for evidence-based medicine. Decision Support Systems, 55, 459–475. [preprint] [doi]
  9. van Valkenhoef, G., Tervonen, T., Zhao, J., de Brock, B., Hillege, H., & Postmus, D. (2012). Multi-criteria benefit-risk assessment using network meta-analysis. Journal of Clinical Epidemiology, 65(4), 394–403. [preprint] [webpage] [doi]
  10. van Valkenhoef, G., Tervonen, T., de Brock, B., & Hillege, H. (2012). Algorithmic Parameterization of Mixed Treatment Comparisons. Statistics and Computing, 22(5), 1099–1111. [preprint] [doi]
  11. van Valkenhoef, G., Tervonen, T., de Brock, B., & Postmus, D. (2011). Quantitative release planning in Extreme Programming. Information and Software Technology, 53(11), 1227–1235. [preprint] [doi]
  12. Vlaar, P. J., Mahmoud, K. D. E., jr., D. R. H., van Valkenhoef, G., Hillege, H. L., van der Horst, I. C. C., … de Smet, B. J. G. L. (2011). Culprit vessel only versus multivessel and staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-elevation myocardial infarction. A pairwise and network meta-analysis. Journal of the American College of Cardiology, 58(7), 692–703. [doi]
  13. Tervonen, T., van Valkenhoef, G., Buskens, E., Hillege, H. L., & Postmus, D. (2011). A stochastic multicriteria model for evidence-based decision making in drug benefit-risk analysis. Statistics in Medicine, 30(12), 1419–1428. [preprint] [webpage] [doi]

Conference proceedings

  1. van Valkenhoef, G., & Kuiper, J. (2014). Crowdsourcing a comprehensive clinical trial repository. In Proceedings of the AAI Workshop on Modern Artificial Intelligence for Health Analytics (MAIHA 2014), July 27, 2014, Québec City, Québec, Canada. [preprint]
  2. Kuiper, J., & van Valkenhoef, G. (2013). Top-level MeSH Disease Categories Are Not Linearly Separable in Clinical Trial Abstracts. In Proceedings of the 14th Conference on Artificial Intelligence in Medicine (AIME2013), May 29 - June 1, 2013, Murcia, Spain. [preprint] [slides] [poster]
  3. Sun, Y., van Valkenhoef, G., & Morel, T. (2012). A Mixed Treatment Comparison of Gabapentin Enacarbil, Pramipexole, Ropinirole and Rotigotine in Moderate-to-Severe Restless Legs Syndrome (RLS). In Value in Health (Vol. 15, p. A546). [doi]
  4. Tervonen, T., de Brock, E. O., de Graeff, P. A., & Hillege, H. L. (2010). Current status and future perspectives on Drug Information Systems. In Proceedings of the 18th European Conference on Information Systems (ECIS2010), June 6-9, 2010, Pretoria, South Africa. [preprint] [slides]
  5. van Valkenhoef, G., Tervonen, T., de Brock, E. O., & Postmus, D. (2010). Product and Release planning practices for Extreme Programming. In Lecture Notes in Business Information Processing (Vol. 48, pp. 238–243). Proceedings of the 11th International Conference on Agile Software Development (XP2010), June 1-4, 2010, Trondheim, Norway. [preprint] [slides] [doi]
  6. Tervonen, T. (2010). JSMAA: an open source software for SMAA computations. In C. H. Antunes, D. R. Insua, & L. C. Dias (Eds.), Proceedings of the 25th Mini EURO Conference on Uncertainty and Robustness in Planning and Decision Making (URPDM2010), April 15-17, 2010, Coimbra, Portugal. [preprint] [slides]

Theses

  1. Goeree, B. N. (2014). Decision support for cost-effectiveness analysis of health care interventions: extending ADDIS (Master's thesis). Industrial Engineering and Management, Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, The Netherlands. [preprint] [slides]
  2. van Valkenhoef, G. (2012). Making better use of clinical trials: computational decision support methods for evidence-based drug benefit-risk assessment (PhD thesis). Graduate School Medical Sciences, University of Groningen, Groningen, The Netherlands. [eprint] [preprint]
  3. Zhao, J. (2012). How To Handle Dependent Events In Clinical Decision Making? A Case Study In Heart Failure. (Master's thesis). Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. [preprint]
  4. Kileo, M. V. (2011). Pattern-based architecture of a system for systematic review of clinical trials (Master's thesis). Department of Computer Science, University of Groningen, Groningen, The Netherlands. [eprint] [preprint] [slides]
  5. Zhao, J. (2010). Pairwise- and mixed treatment comparison models in multicriteria benefit-risk analysis (Master's thesis). Engineering and Management of Information Systems, Department of Computer and Systems Sciences, Royal Institute of Technology (KTH), Stockholm, Sweden. [preprint] [slides]

Research reports

  1. Goeree, B. N. (2014). Using network meta-analysis to inform the transition probabilities of a cost-effectiveness analysis. Industrial Engineering and Management, Faculty of Mathematics and Natural Sciences, University of Groningen. [preprint] [slides]
  2. van Leeuwen, H. (2013). Results of the questionnaire on benefit-risk analysis with the ADDIS software: Executive Summary. drugis.org. [preprint]
  3. Aerts, J., & the ADDIS development team. (2013). ADDIS - Standard for Exchange of Aggregated Data in Clinical Research - Specification Document version 1.0. drugis.org.
  4. Zhao, J., van Valkenhoef, G., de Brock, B., & Hillege, H. (2012). ADDIS: an automated way to do network meta-analysis (No. 12007-Other). School of Management, Faculty of Economics and Business, University of Groningen. [eprint] [preprint] [dataset]
  5. van Valkenhoef, G., Tervonen, T., de Brock, B., & Hillege, H. (2012). Clinical trials evidence in drug development and regulation: a survey of existing systems and standards (No. 12003-Other). School of Management, Faculty of Economics and Business, University of Groningen. [eprint] [preprint]
  6. Tervonen, T., Hillege, H. L., Buskens, E., & Postmus, D. (2010). A state-of-the-art multi-criteria model for drug benefit-risk analysis (No. 10001). School of Management, Faculty of Economics and Business, University of Groningen. [eprint] [preprint]

Abstracts and presentations

  1. van Valkenhoef, G. (2014). ADDIS: towards on-demand support for evidence based decision making based on structured data sources. Presentation at ClinicalTrials.gov, NLM, NIH, Bethesda MD, 21 November 2014. [slides]
  2. van Valkenhoef, G. (2014). ADDIS: the promise of structured data for evidence-based medicine. Presentation at the Fall EPC meeting, AHRQ, Rockville MD, 20 November 2014. [slides]
  3. van Valkenhoef, G. (2014). Multiple criteria decision analysis (MCDA) for drug benefit-risk assessment. Presentation at the Biostatistics seminar, Brown University, 17 November 2014. [slides]
  4. van Valkenhoef, G. (2014). Structuring Data for Evidence-Based Medicine: Challenges and Opportunities. Presentation at the dbread seminar, Computer Science, Brown University, 12 November 2014. [slides]
  5. van Valkenhoef, G., Reid, D., & Stroomberg, C. (2014). ADDIS 2 progress, Jan-Aug 2014. Presentation at the Getreal WP4 face to face meeting, Diemen, The Netherlands, 3 September 2014. [slides]
  6. Kuiper, J. (2014). Resurrecting documents – automatically extracting structure from PDFs. Presentation at the Social Epidemiology unit meeting, University Medical Center Groningen, 16 June 2014, Groningen, The Netherlands. [slides]
  7. van Valkenhoef, G. (2014). Software deliverables GetReal WP4. Presentation at the GetReal WP4 teleconference, 25 April 2014. [slides]
  8. Wallace, B. (2014). Machine Learning in Evidence-Based Medicine: Taming the Clinical Data Deluge. Presentation at the SHARE seminar, University Medical Center Groningen, 24 April 2014, Groningen, The Netherlands. [abstract] [slides]
  9. Goeree, B. (2014). Decision support for cost-effectiveness analysis of healthcare interventions. Presentation at the HTA unit meeting, University Medical Center Groningen, 17 April 2014, Groningen, The Netherlands. [slides]
  10. Hillege, H., Postmus, D., van Valkenhoef, G., Goeree, B., & de Brock, B. (2014). ADDIS. Presentation at College voor Zorgverzekeringen, 27 March 2014, Diemen, The Netherlands. [slides]
  11. Tervonen, T. (2014). Multi-criteria decision analysis in health care: preference models and elicitation methods for benefit-risk assessment. Presentation at the Health Economics Seminar, Erasmus University, 18 March 2014, Rotterdam, The Netherlands. [slides]
  12. van Valkenhoef, G., Reid, D., & Stroomberg, C. (2014). The ADDIS software for evidence based health care policy. Presentation at the WP4 session of the IMI GetReal kick-off meeting, 29 January 2014, Zeist, The Netherlands. [slides]
  13. Kuiper, J. (2013). Reproducible Science: how to deal with the entanglement of data, methods, code and publications. Presentation at Epidemiology, University Medical Center Groningen, 14 November 2013, Groningen, The Netherlands. [slides]
  14. van Valkenhoef, G. (2013). The expanding scope of comparative effectiveness research requires collaborative IT solutions. Poster presentation at the ISPOR 16th Annual European Congress, 2-6 November 2013, Dublin, Ireland. [abstract] [poster]
  15. van Valkenhoef, G. (2013). The ADDIS software for evidence based health care policy. Presentation at Epidemiology, University Medical Center Groningen, 17 October 2013, Groningen, The Netherlands. [slides]
  16. van Valkenhoef, G. (2013). Software for Network Meta-Analysis. Workshop at the Symposium "Translating Research Evidence into Practice" of the Veterans General Hospital, 5-6 October, Taipei, Taiwan. [abstract] [slides] [handout]
  17. Postmus, D. (2013). Benefit and Risk Considerations in Clinical Decision Making - Practical Tips; a User Case from Drugs. Workshop at the Symposium "Translating Research Evidence into Practice" of the Veterans General Hospital, 5-6 October, Taipei, Taiwan. [abstract] [slides]
  18. Postmus, D. (2013). Benefit and Risk Considerations in Clinical Decision Making. Keynote at the Symposium "Translating Research Evidence into Practice" of the Veterans General Hospital, 5-6 October, Taipei, Taiwan. [abstract] [slides]
  19. van Valkenhoef, G., & Tervonen, T. (2013). Optimal weight constraint elicitation for additive multi-attribute utility models. Presentation at the 26th European Conference on Operational Research (EURO 2013), July 1-4, 2013, Rome, Italy. [abstract] [slides]
  20. van Valkenhoef, G. (2013). Modeling inconsistency as heterogeneity in network meta-analysis. Presentation at the 8th annual meeting of the Society for Research Synthesis Methods (SRSM), June 26-28, 2013, Providence, Rhode Island, USA. [abstract] [slides]
  21. van Valkenhoef, G. (2013). Software for (Bayesian) network meta-analysis. Invited presentation at the Swiss Epidemiology Winter School, 23 January 2013, Wengen, Switzerland. [slides]
  22. van Valkenhoef, G. (2012). Decision support software for benefit-risk assessment. Presentation at the Escher Workshop "Towards Adaptive Marketing Authorization", 6-7 December 2012, Amsterdam, The Netherlands. [slides]
  23. van Valkenhoef, G., Tervonen, T., Basturk, N., & Postmus, D. (2012). ’Hit and Run’ for the efficient generation of weights. Presentation at the 25th European Conference on Operational Research (EURO 2012), July 8-11, 2012, Vilnius, Lithuania. [abstract] [slides]
  24. van Valkenhoef, G., Dias, S., Ades, A. E., & Welton, N. J. (2012). Automated generation of node-split models for the assessment of inconsistency in mixed treatment comparisons. Presentation at the 7th annual meeting of the Society for Research Synthesis Methodology (SRSM), June 28-30, 2012, Aix-en-Provence, France. [abstract] [slides]
  25. Dias, S., & van Valkenhoef, G. (2012). Generalized models and software for network meta-analysis. Invited presentation at the Tufts summer conference on network meta-analysis software, June 18-20, 2012, Boston MA, USA. [slides]
  26. Tervonen, T., van Valkenhoef, G., Basturk, N., & Postmus, D. (2012). Efficient weight generation for simulation-based multiple criteria decision analysis. Presentation at the 75th meeting of the European Working Group in Multiple Criteria Decision Aid (MCDA 75), April 12-14, 2012, Tarragona, Spain. [abstract] [slides]
  27. van Valkenhoef, G. (2012). Automating network meta-analysis. Invited presentation at the Health Economics Journal Club, University of Groningen, 7 March 2012, Groningen, The Netherlands. [slides]
  28. van Valkenhoef, G. (2011). Automated decision support for evidence-based benefit-risk decision making. Presentation at the project Escher meeting, 2 December 2011, Amersfoort, The Netherlands. [abstract] [slides] [video]
  29. Postmus, D., Tervonen, T., Hillege, H., & Buskens, E. (2011). Increasing the transparency of healthcare reimbursement decisions by using multi-criteria analysis. Presentation at the 21st International Conference on Multiple Criteria Decision Making (MCDM 2011), 13-17 June 2011, Jyväskylä, Finland. [abstract] [slides]
  30. van Valkenhoef, G., de Brock, B., & Hillege, H. L. (2011). ADDIS: multi-criteria decision support for evidence-based medicine. Presentation at the 21st International Conference on Multiple Criteria Decision Making (MCDM 2011), 13-17 June 2011, Jyväskylä, Finland. [abstract] [slides]
  31. Zhao, J., van Valkenhoef, G., & Hillege, H. L. (2011). Mixed treatment comparison in multi-criteria benefit-risk analysis applied to four second-generation anti-depressants. Presentation at the annual epidemiology conference WEON 2011, 9-10 June 2011, IJmuiden, The Netherlands. [poster]
  32. van Valkenhoef, G., & Martikainen, J. (2011). Novel quantitative methods in the evaluation of therapeutic and economic value of medicines. Short course at the School of Pharmacy, University of Eastern Finland, 9-10 June 2011, Kuopio, Finland. [webpage]
  33. van Valkenhoef, G. (2011). Automating network meta-analysis. Presentation at the Academic Unit of Primary Health Care, University of Bristol, 18 April 2011, Bristol, United Kingdom. [abstract] [slides]
  34. van Valkenhoef, G. (2010). Escher Project 3.2: research and software to support benefit-risk decision making. Presentation for the Escher 3.x steering group, 8 December 2010, Utrecht, The Netherlands. [slides]
  35. van Valkenhoef, G. (2010). Network meta-analysis. Presentation at the Department of Clinical Pharmacology, University Medical Center Groningen, 29 November 2010. [slides]
  36. van Valkenhoef, G., de Brock, E. O., & Hillege, H. L. (2010). Multi-criteria drug benefit-risk assessment using network meta-analysis. Poster presentation at the FIGON Dutch Medicines Days, 5 October 2010, Lunteren, The Netherlands. [poster]
  37. van Valkenhoef, G. (2010). Network meta-analysis modelling in benefit-risk assessment. Short presentation at the Project Escher lunch session at the FIGON Dutch Medicines Days, 5 October 2010, Lunteren, The Netherlands. [slides]
  38. Tervonen, T. (2010). Computational methods for evidence-based decision support in pharmaceutical decision making. Presentation at Computational Intelligence in HealthCare, September 20-24, 2010, Eindhoven, the Netherlands. [abstract] [slides]
  39. van Valkenhoef, G., Tervonen, T., de Brock, E. O., Hillege, H. L., & Postmus, D. (2010). Multi-criteria drug benefit-risk assessment through mixed treatment comparisons. Presentation at the 24th European Conference on Operational Research (EURO 2010), July 11-14, 2010, Lisbon, Portugal. [abstract] [slides]
  40. Tervonen, T., van Valkenhoef, G., de Brock, E. O., & Postmus, D. (2010). Quantitative release planning in Extreme Programming. Presentation at the 24th European Conference on Operational Research (EURO 2010), July 11-14, 2010, Lisbon, Portugal. [abstract] [slides]
  41. Postmus, D., Tervonen, T., Hillege, H. L., & Buskens, E. (2010). SMAA-CEA: a new method for representing decision uncertainty in cost-effectiveness analysis when three or more alternatives are being compared. Presentation at the 8th European Conference on Health Economics (ECHE 2010), July 7-10, 2010, Helsinki, Finland. [abstract] [slides]
  42. Tervonen, T. (2010). ADDIS: Aggregate Data Drug Information System for drug benefit-risk analysis and automated evidence synthesis. Presentation at the Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, June 11, 2010, Florianópolis, Brazil. [abstract] [slides]
  43. Tervonen, T. (2010). Stochastic Multicriteria Acceptability Analysis (SMAA): theory, applications, and software. Invited presentation in ALIO/INFORMS joint international meeting, June 6-9, 2010, Buenos Aires, Argentina. [abstract] [slides]
  44. Postmus, D., Tervonen, T., Hillege, H. L., & Buskens, E. (2010). Using stochastic multicriteria acceptability analysis to assess the cost-effectiveness of healthcare interventions: a case study in heart failure. Invited presentation in ALIO/INFORMS joint international meeting, June 6-9, 2010, Buenos Aires, Argentina. [abstract] [slides]
  45. van Valkenhoef, G. (2010). Network meta-analysis:an introduction and example. Presentation at Epidemiology, University Medical Center Groningen, May 27, 2010, Groningen, The Netherlands. [slides]
  46. van Valkenhoef, G., Bayer, A., Tervonen, T., Zhao, J., de Brock, B., & Hillege, H. (2010). Escher 3.2 Poster. Poster presentation at the Escher workshop "Barriers to pharmaceutical innovation", April 28, 2010, Leiden, The Netherlands. [poster]
  47. van Valkenhoef, G., Tervonen, T., Koeslag, H., de Brock, B., Hillege, H., & Zwinkels, T. (2010). Aggregate Data Drug Information System (ADDIS): an open source tool for clinical trial analysis. Poster presentation at the TI Pharma Spring Meeting, April 15, 2010, Utrecht, The Netherlands. [poster]
  48. Tervonen, T. (2010). Multi-criteria decision support for evidence-based decision making. Presentation at Econometrics, Erasmus University Rotterdam, March 25, 2010, Rotterdam, The Netherlands. [slides]
  49. van Valkenhoef, G. (2009). ADDIS: Software for Clinical Trials Data Analysis. Presentation at the Project Escher session at the FIGON Dutch Medicines Days, 12 October 2009, Lunteren, The Netherlands. [slides]
  50. van Valkenhoef, G. (2009). Escher 3.2: Exploratory Software Development. Colloquium of the Department of Business & ICT / University of Groningen, September 2009, Groningen. [slides]
  51. Tervonen, T., Hillege, H. L., & Postmus, D. (2009). Multi-criteria benefit-risk analysis of Viagra, Levitra, and Cialis. Invited presentation at the 23rd European conference on Operational Research, July 2009, Bonn. [slides]
  52. Tervonen, T., Postmus, D., & Hillege, H. L. (2009). Multi-criteria decision analysis in drug benefit-risk assessment. 69th meeting of the EURO Working Group on MCDA, April 2009, Brussels. [slides]
  53. Tervonen, T., Hillege, H. L., & Postmus, D. (2009). A state-of-the-art multi-criteria model for drug benefit-risk analysis. Poster presentation at the TI-Pharma Spring Meeting, April 2009, Utrecht. [poster]
  54. Tervonen, T., Oskuee, S., de Brock, E. O., de Graeff, P. A., & Hillege, H. L. (2009). Current status and future perspectives of Drug Information Systems. Poster presention at the TI-Pharma Spring Meeting, April 2009, Utrecht. [slides]
  55. Tervonen, T. (2009). Drug regulatory process, the supporting information systems, and the Escher-project. Colloquium of the Department of Business & ICT / University of Groningen, December 2008, Groningen. [slides]