Publications

Journal articles

  1. van Valkenhoef, G., Tervonen, T., & Postmus, D. (2014). Notes on ’Hit-And-Run enables efficient weight generation for simulation-based multiple criteria decision analysis’. European Journal of Operational Research. in press. [preprint] [doi]
  2. Postmus, D., Tervonen, T., van Valkenhoef, G., Hillege, H., & Buskens, E. (2013). A multi-criteria decision analysis perspective on the health economic evaluation of medical interventions. The European Journal of Health Economics. in press. [preprint] [doi]
  3. van Valkenhoef, G., & Ades, A. E. (2013). Evidence synthesis assumes additivity on the scale of measurement: response to ’rank reversal in indirect comparisons’ by Norton et al. Value in Health, 16, 449-451. [preprint] [doi]
  4. Tervonen, T., van Valkenhoef, G., Basturk, N., & Postmus, D. (2012). Hit-And-Run enables efficient weight generation for simulation-based multiple criteria decision analysis. European Journal of Operational Research, 224(3), 552–559. [preprint] [webpage] [doi]
  5. van Valkenhoef, G., Tervonen, T., de Brock, B., & Hillege, H. (2012). Deficiencies in the transfer and availability of clinical trials evidence: a review of existing systems and standards. BMC Medical Informatics and Decision Making, 12, 95. [preprint] [doi]
  6. van Valkenhoef, G., Lu, G., de Brock, B., Hillege, H., Ades, A. E., & Welton, N. J. (2012). Automating network meta-analysis. Research Synthesis Methods, 3(4), 285–299. [preprint] [doi]
  7. Tervonen, T. (2012). JSMAA: open source software for SMAA computations. International Journal of Systems Science, in press. [doi]
  8. van Valkenhoef, G., Tervonen, T., Zwinkels, T., de Brock, B., & Hillege, H. (2013). ADDIS: a decision support system for evidence-based medicine. Decision Support Systems, 55, 459–475. [preprint] [doi]
  9. van Valkenhoef, G., Tervonen, T., Zhao, J., de Brock, B., Hillege, H., & Postmus, D. (2012). Multi-criteria benefit-risk assessment using network meta-analysis. Journal of Clinical Epidemiology, 65(4), 394–403. [preprint] [webpage] [doi]
  10. van Valkenhoef, G., Tervonen, T., de Brock, B., & Hillege, H. (2012). Algorithmic Parameterization of Mixed Treatment Comparisons. Statistics and Computing, 22(5), 1099–1111. [preprint] [doi]
  11. van Valkenhoef, G., Tervonen, T., de Brock, B., & Postmus, D. (2011). Quantitative release planning in Extreme Programming. Information and Software Technology, 53(11), 1227–1235. [preprint] [doi]
  12. Vlaar, P. J., Mahmoud, K. D. E., jr., D. R. H., van Valkenhoef, G., Hillege, H. L., van der Horst, I. C. C., Zijlstra, F., & de Smet, B. J. G. L. (2011). Culprit vessel only versus multivessel and staged percutaneous coronary intervention for multivessel disease in patients presenting with ST-elevation myocardial infarction. A pairwise and network meta-analysis. Journal of the American College of Cardiology, 58(7), 692–703. [doi]
  13. Tervonen, T., van Valkenhoef, G., Buskens, E., Hillege, H. L., & Postmus, D. (2011). A stochastic multicriteria model for evidence-based decision making in drug benefit-risk analysis. Statistics in Medicine, 30(12), 1419–1428. [preprint] [webpage] [doi]

Conference proceedings

  1. van Valkenhoef, G., & Kuiper, J. (2014). Crowdsourcing a comprehensive clinical trial repository. In Proceedings of the AAI Workshop on Modern Artificial Intelligence for Health Analytics (MAIHA 2014), July 27, 2014, Québec City, Québec, Canada. [preprint]
  2. Kuiper, J., & van Valkenhoef, G. (2013). Top-level MeSH Disease Categories Are Not Linearly Separable in Clinical Trial Abstracts. In Proceedings of the 14th Conference on Artificial Intelligence in Medicine (AIME2013), May 29 - June 1, 2013, Murcia, Spain. [preprint] [slides] [poster]
  3. Sun, Y., van Valkenhoef, G., & Morel, T. (2012). A Mixed Treatment Comparison of Gabapentin Enacarbil, Pramipexole, Ropinirole and Rotigotine in Moderate-to-Severe Restless Legs Syndrome (RLS). In Value in Health (ISPOR 15th Annual European Congress and ISPOR 5th Asia-Pacific Conference) (Vol. 15, A546). [doi]
  4. Tervonen, T., de Brock, E. O., de Graeff, P. A., & Hillege, H. L. (2010). Current status and future perspectives on Drug Information Systems. In Proceedings of the 18th European Conference on Information Systems (ECIS2010), June 6-9, 2010, Pretoria, South Africa. [preprint] [slides]
  5. van Valkenhoef, G., Tervonen, T., de Brock, E. O., & Postmus, D. (2010). Product and Release planning practices for Extreme Programming. In Lecture Notes in Business Information Processing (Vol. 48, 238–243). Proceedings of the 11th International Conference on Agile Software Development (XP2010), June 1-4, 2010, Trondheim, Norway. [preprint] [slides] [doi]
  6. Tervonen, T. (2010). JSMAA: an open source software for SMAA computations. In C. H. Antunes, D. R. Insua & L. C. Dias (Eds.), Proceedings of the 25th Mini EURO Conference on Uncertainty and Robustness in Planning and Decision Making (URPDM2010), April 15-17, 2010, Coimbra, Portugal.. [preprint] [slides]

Theses

  1. van Valkenhoef, G. (2012). Making better use of clinical trials: computational decision support methods for evidence-based drug benefit-risk assessment (PhD thesis). Groningen, The Netherlands. [eprint] [preprint]
  2. Zhao, J. (2012). How To Handle Dependent Events In Clinical Decision Making? A Case Study In Heart Failure. (Master's thesis). Groningen, The Netherlands. [preprint]
  3. Kileo, M. V. (2011). Pattern-based architecture of a system for systematic review of clinical trials (Master's thesis). Groningen, The Netherlands. [eprint] [preprint] [slides]
  4. Zhao, J. (2010). Pairwise- and mixed treatment comparison models in multicriteria benefit-risk analysis (Master's thesis). Stockholm, Sweden. [preprint] [slides]

Research reports

  1. van Leeuwen, H. (2013). Results of the questionnaire on benefit-risk analysis with the ADDIS software: Executive Summary. [preprint]
  2. Aerts, J., & the ADDIS development team. (2013). ADDIS - Standard for Exchange of Aggregated Data in Clinical Research - Specification Document version 1.0. [preprint]
  3. Zhao, J., van Valkenhoef, G., de Brock, B., & Hillege, H. (2012). ADDIS: an automated way to do network meta-analysis. [eprint] [preprint] [dataset]
  4. van Valkenhoef, G., Tervonen, T., de Brock, B., & Hillege, H. (2012). Clinical trials evidence in drug development and regulation: a survey of existing systems and standards. [eprint] [preprint]
  5. Tervonen, T., Hillege, H. L., Buskens, E., & Postmus, D. (2010). A state-of-the-art multi-criteria model for drug benefit-risk analysis. [eprint] [preprint]

Abstracts and presentations

  1. Kuiper, J. (2014). Resurrecting documents – automatically extracting structure from PDFs. Presentation at the Social Epidemiology unit meeting, University Medical Center Groningen, 16 June 2014, Groningen, The Netherlands. [slides]
  2. van Valkenhoef, G. (2014). Software deliverables GetReal WP4. Presentation at the GetReal WP4 teleconference, 25 April 2014. [slides]
  3. Wallace, B. (2014). Machine Learning in Evidence-Based Medicine: Taming the Clinical Data Deluge. Presentation at the SHARE seminar, University Medical Center Groningen, 24 April 2014, Groningen, The Netherlands. [abstract] [slides]
  4. Goeree, B. (2014). Decision support for cost-effectiveness analysis of healthcare interventions. Presentation at the HTA unit meeting, University Medical Center Groningen, 17 April 2014, Groningen, The Netherlands. [slides]
  5. Hillege, H., Postmus, D., van Valkenhoef, G., Goeree, B., & de Brock, B. (2014). ADDIS. Presentation at College voor Zorgverzekeringen, 27 March 2014, Diemen, The Netherlands. [slides]
  6. Tervonen, T. (2014). Multi-criteria decision analysis in health care: preference models and elicitation methods for benefit-risk assessment. Presentation at the Health Economics Seminar, Erasmus University, 18 March 2014, Rotterdam, The Netherlands. [slides]
  7. van Valkenhoef, G., Reid, D., & Stroomberg, C. (2014). The ADDIS software for evidence based health care policy. Presentation at the WP4 session of the IMI GetReal kick-off meeting, 29 January 2014, Zeist, The Netherlands. [slides]
  8. Kuiper, J. (2013). Reproducible Science: how to deal with the entanglement of data, methods, code and publications. Presentation at Epidemiology, University Medical Center Groningen, 14 November 2013, Groningen, The Netherlands. [slides]
  9. van Valkenhoef, G. (2013). The expanding scope of comparative effectiveness research requires collaborative IT solutions. Poster presentation at the ISPOR 16th Annual European Congress, 2-6 November 2013, Dublin, Ireland. [abstract] [poster]
  10. van Valkenhoef, G. (2013). The ADDIS software for evidence based health care policy. Presentation at Epidemiology, University Medical Center Groningen, 17 October 2013, Groningen, The Netherlands. [slides]
  11. van Valkenhoef, G. (2013). Software for Network Meta-Analysis. Workshop at the Symposium "Translating Research Evidence into Practice" of the Veterans General Hospital, 5-6 October, Taipei, Taiwan. [abstract] [slides] [handout]
  12. Postmus, D. (2013). Benefit and Risk Considerations in Clinical Decision Making - Practical Tips; a User Case from Drugs. Workshop at the Symposium "Translating Research Evidence into Practice" of the Veterans General Hospital, 5-6 October, Taipei, Taiwan. [abstract] [slides]
  13. Postmus, D. (2013). Benefit and Risk Considerations in Clinical Decision Making. Keynote at the Symposium "Translating Research Evidence into Practice" of the Veterans General Hospital, 5-6 October, Taipei, Taiwan. [abstract] [slides]
  14. van Valkenhoef, G., & Tervonen, T. (2013). Optimal weight constraint elicitation for additive multi-attribute utility models. Presentation at the 26th European Conference on Operational Research (EURO 2013), July 1-4, 2013, Rome, Italy. [abstract] [slides]
  15. van Valkenhoef, G. (2013). Modeling inconsistency as heterogeneity in network meta-analysis. Presentation at the 8th annual meeting of the Society for Research Synthesis Methods (SRSM), June 26-28, 2013, Providence, Rhode Island, USA. [abstract] [slides]
  16. van Valkenhoef, G. (2013). Software for (Bayesian) network meta-analysis. Invited presentation at the Swiss Epidemiology Winter School, 23 January 2013, Wengen, Switzerland. [slides]
  17. van Valkenhoef, G. (2012). Decision support software for benefit-risk assessment. Presentation at the Escher Workshop "Towards Adaptive Marketing Authorization", 6-7 December 2012, Amsterdam, The Netherlands. [slides]
  18. van Valkenhoef, G., Tervonen, T., Basturk, N., & Postmus, D. (2012). ’Hit and Run’ for the efficient generation of weights. Presentation at the 25th European Conference on Operational Research (EURO 2012), July 8-11, 2012, Vilnius, Lithuania. [abstract] [slides]
  19. van Valkenhoef, G., Dias, S., Ades, A. E., & Welton, N. J. (2012). Automated generation of node-split models for the assessment of inconsistency in mixed treatment comparisons. Presentation at the 7th annual meeting of the Society for Research Synthesis Methodology (SRSM), June 28-30, 2012, Aix-en-Provence, France. [abstract] [slides]
  20. Dias, S., & van Valkenhoef, G. (2012). Generalized models and software for network meta-analysis. Invited presentation at the Tufts summer conference on network meta-analysis software, June 18-20, 2012, Boston MA, USA. [slides]
  21. Tervonen, T., van Valkenhoef, G., Basturk, N., & Postmus, D. (2012). Efficient weight generation for simulation-based multiple criteria decision analysis. Presentation at the 75th meeting of the European Working Group in Multiple Criteria Decision Aid (MCDA 75), April 12-14, 2012, Tarragona, Spain. [abstract] [slides]
  22. van Valkenhoef, G. (2012). Automating network meta-analysis. Invited presentation at the Health Economics Journal Club, University of Groningen, 7 March 2012, Groningen, The Netherlands. [slides]
  23. van Valkenhoef, G. (2011). Automated decision support for evidence-based benefit-risk decision making. Presentation at the project Escher meeting, 2 December 2011, Amersfoort, The Netherlands. [abstract] [slides] [video]
  24. Postmus, D., Tervonen, T., Hillege, H., & Buskens, E. (2011). Increasing the transparency of healthcare reimbursement decisions by using multi-criteria analysis. Presentation at the 21st International Conference on Multiple Criteria Decision Making (MCDM 2011), 13-17 June 2011, Jyväskylä, Finland. [abstract] [slides]
  25. van Valkenhoef, G., de Brock, B., & Hillege, H. L. (2011). ADDIS: multi-criteria decision support for evidence-based medicine. Presentation at the 21st International Conference on Multiple Criteria Decision Making (MCDM 2011), 13-17 June 2011, Jyväskylä, Finland. [abstract] [slides]
  26. Zhao, J., van Valkenhoef, G., & Hillege, H. L. (2011). Mixed treatment comparison in multi-criteria benefit-risk analysis applied to four second-generation anti-depressants. Presentation at the annual epidemiology conference WEON 2011, 9-10 June 2011, IJmuiden, The Netherlands. [poster]
  27. van Valkenhoef, G., & Martikainen, J. (2011). Novel quantitative methods in the evaluation of therapeutic and economic value of medicines.. Short course at the School of Pharmacy, University of Eastern Finland, 9-10 June 2011, Kuopio, Finland. [webpage]
  28. van Valkenhoef, G. (2011). Automating network meta-analysis. Presentation at the Academic Unit of Primary Health Care, University of Bristol, 18 April 2011, Bristol, United Kingdom. [abstract] [slides]
  29. van Valkenhoef, G. (2010). Escher Project 3.2: research and software to support benefit-risk decision making.. Presentation for the Escher 3.x steering group, 8 December 2010, Utrecht, The Netherlands. [slides]
  30. van Valkenhoef, G. (2010). Network meta-analysis. Presentation at the Department of Clinical Pharmacology, University Medical Center Groningen, 29 November 2010. [slides]
  31. van Valkenhoef, G., de Brock, E. O., & Hillege, H. L. (2010). Multi-criteria drug benefit-risk assessment using network meta-analysis. Poster presentation at the FIGON Dutch Medicines Days, 5 October 2010, Lunteren, The Netherlands. [poster]
  32. van Valkenhoef, G. (2010). Network meta-analysis modelling in benefit-risk assessment. Short presentation at the Project Escher lunch session at the FIGON Dutch Medicines Days, 5 October 2010, Lunteren, The Netherlands. [slides]
  33. Tervonen, T. (2010). Computational methods for evidence-based decision support in pharmaceutical decision making. Presentation at Computational Intelligence in HealthCare, September 20-24, 2010, Eindhoven, the Netherlands. [abstract] [slides]
  34. van Valkenhoef, G., Tervonen, T., de Brock, E. O., Hillege, H. L., & Postmus, D. (2010). Multi-criteria drug benefit-risk assessment through mixed treatment comparisons. Presentation at the 24th European Conference on Operational Research (EURO 2010), July 11-14, 2010, Lisbon, Portugal. [abstract] [slides]
  35. Tervonen, T., van Valkenhoef, G., de Brock, E. O., & Postmus, D. (2010). Quantitative release planning in Extreme Programming. Presentation at the 24th European Conference on Operational Research (EURO 2010), July 11-14, 2010, Lisbon, Portugal. [abstract] [slides]
  36. Postmus, D., Tervonen, T., Hillege, H. L., & Buskens, E. (2010). SMAA-CEA: a new method for representing decision uncertainty in cost-effectiveness analysis when three or more alternatives are being compared. Presentation at the 8th European Conference on Health Economics (ECHE 2010), July 7-10, 2010, Helsinki, Finland. [abstract] [slides]
  37. Tervonen, T. (2010). ADDIS: Aggregate Data Drug Information System for drug benefit-risk analysis and automated evidence synthesis. Presentation at the Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, June 11, 2010, Florianópolis, Brazil. [abstract] [slides]
  38. Tervonen, T. (2010). Stochastic Multicriteria Acceptability Analysis (SMAA): theory, applications, and software. Invited presentation in ALIO/INFORMS joint international meeting, June 6-9, 2010, Buenos Aires, Argentina. [abstract] [slides]
  39. Postmus, D., Tervonen, T., Hillege, H. L., & Buskens, E. (2010). Using stochastic multicriteria acceptability analysis to assess the cost-effectiveness of healthcare interventions: a case study in heart failure. Invited presentation in ALIO/INFORMS joint international meeting, June 6-9, 2010, Buenos Aires, Argentina. [abstract] [slides]
  40. van Valkenhoef, G. (2010). Network meta-analysis:an introduction and example. Presentation at Epidemiology, University Medical Center Groningen, May 27, 2010, Groningen, The Netherlands. [slides]
  41. van Valkenhoef, G., Bayer, A., Tervonen, T., Zhao, J., de Brock, B., & Hillege, H. (2010). Escher 3.2 Poster. Poster presentation at the Escher workshop "Barriers to pharmaceutical innovation", April 28, 2010, Leiden, The Netherlands. [poster]
  42. van Valkenhoef, G., Tervonen, T., Koeslag, H., de Brock, B., Hillege, H., & Zwinkels, T. (2010). Aggregate Data Drug Information System (ADDIS): an open source tool for clinical trial analysis. Poster presentation at the TI Pharma Spring Meeting, April 15, 2010, Utrecht, The Netherlands. [poster]
  43. Tervonen, T. (2010). Multi-criteria decision support for evidence-based decision making. Presentation at Econometrics, Erasmus University Rotterdam, March 25, 2010, Rotterdam, The Netherlands. [slides]
  44. van Valkenhoef, G. (2009). ADDIS: Software for Clinical Trials Data Analysis. Presentation at the Project Escher session at the FIGON Dutch Medicines Days, 12 October 2009, Lunteren, The Netherlands. [slides]
  45. van Valkenhoef, G. (2009). Escher 3.2: Exploratory Software Development. Colloquium of the Department of Business & ICT / University of Groningen, September 2009, Groningen. [slides]
  46. Tervonen, T., Hillege, H. L., & Postmus, D. (2009). Multi-criteria benefit-risk analysis of Viagra, Levitra, and Cialis. Invited presentation at the 23rd European conference on Operational Research, July 2009, Bonn. [slides]
  47. Tervonen, T., Postmus, D., & Hillege, H. L. (2009). Multi-criteria decision analysis in drug benefit-risk assessment. 69th meeting of the EURO Working Group on MCDA, April 2009, Brussels. [slides]
  48. Tervonen, T., Hillege, H. L., & Postmus, D. (2009). A state-of-the-art multi-criteria model for drug benefit-risk analysis. Poster presentation at the TI-Pharma Spring Meeting, April 2009, Utrecht. [poster]
  49. Tervonen, T., Oskuee, S., de Brock, E. O., de Graeff, P. A., & Hillege, H. L. (2009). Current status and future perspectives of Drug Information Systems. Poster presention at the TI-Pharma Spring Meeting, April 2009, Utrecht. [slides]
  50. Tervonen, T. (2009). Drug regulatory process, the supporting information systems, and the Escher-project. Colloquium of the Department of Business & ICT / University of Groningen, December 2008, Groningen. [slides]