15 May 2015 — Daan Reid
We are proud to announce the fifth preview version of our web-based redevelopment of ADDIS, ADDIS 2 release 5.
The majority of this release was devoted to the Trialverse component, which is intended to be the portal where users extract and share clinical trials data.
With this release, we will freeze Trialverse development (besides bugfixes) for the near future.
Release 5 contains the following new features:
- Creation of complete studies (general information, design, results)
- Creation of dataset-level concepts (variables, drugs) and their mapping to study-level concepts
- Versioning of datasets (all changes are tracked, previous versions always visible)
- Updated the MCDA component to the latest version
The functionality developed in release 5 is showcased in this video.
The next release will focus on expanding the analysis functionality of ADDIS 2, particularly the network meta-analysis component.
05 May 2015 — Gert van Valkenhoef
We are proud to announce the release of a new version of our web-based Multiple Criteria Decision Analysis (MCDA) tool.
The majority of this release was devoted to polishing the user interface, and introducing a new way of eliciting Partial Value Functions.
We invite everyone to try it out at mcda.drugis.org.
The release contains the following features and bug fixes:
- Remove the MacBeth Partial Value Function elicitation, in favor of a method based on bisection
- Add clear warnings when information will be destroyed
- Add a legend to the heat maps
- Report units of measurement more consistently, and display unbounded intervals correctly
- Add Gravatar support (profile pictures)
- Considerably improve client-side performance
Thanks to Joël Kuiper and Douwe Postmus for their work on this release, and the IMI PROTECT project for their support.
26 Mar 2015 — Gert van Valkenhoef
The ADDIS 1.16.6 release corrects the variance set for continuous outcomes in single-study benefit-risk analyses. It was incorrectly based on the standard deviation of the outcome, rather than the standard error.
06 Feb 2015 — Daan Reid
We are proud to announce the fourth preview version of our web-based redevelopment of ADDIS, ADDIS 2 release 4.
The majority of this release was devoted to the Trialverse component, which is intended to be the portal where users extract and share clinical trials data. Trialverse is not finished yet, but we hope this release gives a good picture of the direction we’re taking. We invite everyone to try it out at trialverse.org.
Release 4 contains the following new features:
- Creation of datasets
- Creation of studies within a dataset
- Definition of study structure, including arms, epochs, and outcome measures.
The functionality developed in release 4 is showcased in this video.
The next release will focus on finishing the Trialverse portal so that complete studies can be entered into the system, and so that users can collaborate to improve previously-entered studies.
21 Jan 2015 — Gert van Valkenhoef
Most importantly, 2014 saw the start of development on ADDIS 2.
We delivered three releases that aimed to prove the feasibility of our architecture and chosen technologies.
At the same time we delivered features that set up the conceptual framework of ADDIS 2 and enabled focused discussions with potential users.
We are now making progress on the data entry and data management component, for which we had to answer a number of difficult open questions regarding our data model and the version management of data sets.
We also set up a software sub-team within work package 4 of IMI GetReal, which will help us prioritize features and gather feedback from project partners.
One of our master students, Bob Goeree, completed his Industrial Engineering and Management internship and MSc project with us.
Bob worked on a prototype of a cost-effectiveness analysis (CEA) component for ADDIS 2, an early demo of which is available on cea.drugis.org.
His MSc thesis extended that work to establish how network meta-analysis should inform such analyses.
His thesis and internship report can be found on the publications page.
Gert van Valkenhoef spent October-December at the Center for Evidence-Based Medicine at Brown University.
During this time, he worked with them on importing projects from their Systematic Review Data Repository into ADDIS 2.
He also gave a number of talks, most notably at the Brown Biostatistics group and at ClinicalTrials.gov.
Slides of these talks are available on the publications page.
Douwe Postmus is visiting the European Medicines Agency to work on the benefit-risk methodology project. This work includes providing guidance and training on reporting benefit-risk considerations and exploring different metholodogies for eliciting patient preferences. Douwe’s work will make use of our MCDA user interface.