News

ADDIS 2 release 8

23 Mar 2016 — Daan Reid

We are proud to announce the eighth preview version of our web-based redevelopment of ADDIS, ADDIS 2 release 8. This release contains the following new features:

  • Integrate data management (formerly "trialverse") into the main ADDIS system (demo video)
  • Network meta-regression analyses (demo video)
  • Downweighting of studies, e.g. non-randomized studies (demo video)
  • Benefit-risk analyses based on meta-analyses (demo video)

The focus of the next release will be divided between three subjects:

  • Definition of concepts such as interventions, e.g. dosage restrictions and combination treatments
  • Importing studies from ClinicalTrials.gov
  • Automatic report generation based on ADDIS projects

GeMTC R package 0.8

01 Mar 2016 — Gert van Valkenhoef

We are proud to announce version 0.8 of our R package for network meta-analysis, GeMTC.

This new version adds support for network meta-regression models and models where some evidence (e.g. observation data) is down-weighted. See GeMTC on CRAN for more information.


ADDIS 2 release 7

27 Nov 2015 — Daan Reid

We are proud to announce the seventh preview version of our web-based redevelopment of ADDIS, ADDIS 2 release 7. This release had several themes. First, we performed user testing for both GeMTC-web and Trialverse. Second, we expanded the network meta-analysis functionality of ADDIS, which is also available as a separate web-application at GeMTC-web. Third, we expanded the study management functionality of Trialverse with search and copying. Fourth, we addressed the most common concerns of our test users.

Release 7 contains the following new features:

  • GeMTC:
    • Inline help for all terminology, along with a brief user's manual.
    • Allow model run length extension.
    • Allow specification of heterogeneity prior.
    • An overview screen for nodesplitting analysis of inconsistency.
    • Several improvements to the user interface based on user feedback.
  • Trialverse:
    • Study search.
    • Allow copying of others' studies to own datasets.

The functionality developed in release 7 is showcased in these videos:

The focus of the next release will be divided between three subjects:

  • Further improvements to the evidence synthesis functionality, including the addition of network meta-regression models.
  • Improving the integration between the ADDIS and Trialverse components.
  • Further user testing of the evidence synthesis functionality.

ADDIS 2 release 6

21 Aug 2015 — Daan Reid

We are proud to announce the sixth preview version of our web-based redevelopment of ADDIS, ADDIS 2 release 6. The majority of this release was devoted to expanding the network meta-analysis functionality of ADDIS. We have also made this functionality available as a separate web-application at gemtc.drugis.org. Release 6 contains the following new features:

  • Support 3 types of meta-analysis (network, pairwise, node-splitting).
  • Allow setting of model parameters (fixed effect vs. random effects, likelihood/link function, run-length parameters).
  • More model results (convergence diagnostics, relative effects plots for network meta-analyses, study effect forest plot for pairwise meta-analyses).

The functionality developed in release 6 is showcased in this video.

The focus of the next release will be divided between three subjects:

  • Expanding Trialverse with features to include others' extractions, and laying groundwork for automating tasks.
  • Further expanding the NMA functionality, allowing inter-model comparisons, the specification of prior distributions, and the exporting of figures and data so they can be used in reports.
  • User testing to improve the usability and stability of the platform.

ADDIS 2 release 5

15 May 2015 — Daan Reid

We are proud to announce the fifth preview version of our web-based redevelopment of ADDIS, ADDIS 2 release 5. The majority of this release was devoted to the Trialverse component, which is intended to be the portal where users extract and share clinical trials data. With this release, we will freeze Trialverse development (besides bugfixes) for the near future. Release 5 contains the following new features:

  • Creation of complete studies (general information, design, results)
  • Creation of dataset-level concepts (variables, drugs) and their mapping to study-level concepts
  • Versioning of datasets (all changes are tracked, previous versions always visible)
  • Updated the MCDA component to the latest version

The functionality developed in release 5 is showcased in this video. The next release will focus on expanding the analysis functionality of ADDIS 2, particularly the network meta-analysis component.